Research roundup: September 2025 edition

Contraceptive knowledge gaps, Adolescent awareness of OTC contraception, DMPA and meningioma risk, Implicit bias in contraception counseling, PrEP & STI Risk
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1. Contraceptive knowledge gaps 

Adolescents and young adults (AYA) often face barriers to high-quality reproductive health care, especially when it comes to accessing accurate contraception information. Limited or poor-quality sex education, compounded by misinformation on social media, can leave many with major gaps in contraceptive knowledge. In this national survey of nearly 1200 participants aged 15-29 years old and assigned female at birth, respondents answered a short series of true/false questions. On average, participants answered half of the questions correctly, and knowledge gaps were more common among younger, Black, heterosexual, and non-urban participants. Fewer than half knew the correct information about not needing to take a break from birth control pills for one’s health, effectiveness of menstrual cycle tracking apps, and the availability of non-contraceptive birth control options. These findings represent an important opportunity for providers seeing AYA patients to provide accurate counseling and education.

2. Adolescent awareness of over-the-counter (OTC) contraception

In 2023, the FDA approved the first over-the-counter (OTC) hormonal contraceptive pill in the US, norgestrel (OPill), available without age restrictions. It became publicly available in 2024. This qualitative study used text message surveys with more than 500 patients aged 14-24 years old to assess adolescent and young adult (AYA) awareness of the OTC birth control pill. Most participants (72%) were unaware of the OTC option, and many expressed concerns about cost, side effects, and stigma. In response to a specific question about anti-theft measures such as lock boxes in retail pharmacies, 78% reported such restrictions would negatively affect AYAs seeking OTC pills, citing concerns about privacy, embarrassment, and shame. The authors discuss the need for awareness campaigns and easily accessible information on side effects and cost, especially for AYA patients.

3. OTC pills and cost effectiveness

In 2023, the US Food and Drug Administration (FDA) approved over-the-counter (OTC) progestin-only pills, expanding access to contraception. This study modeled outcomes for a theoretical population of 1 million reproductive-age females and found that OTC access was cost effective and helped improve users’ quality of life. The model projected cost-savings of up to $1 billion across both abortion-protective and abortion restrictive settings by helping patients prevent unintended pregnancy, ectopic pregnancy, abortion and associated travel, and other complications. Cost-effectiveness held even without insurance coverage. The authors conclude that OTC contraception offers broad public health benefits and can inform policy and advocacy efforts to expand insurance coverage and improve patient education. 

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