Nexplanon REMS Requirements: What Providers Need to Know

Estimated reading time: 4 minutes

Nexplanon is now FDA-approved for up to 5 years of pregnancy prevention, reflecting evidence many providers were already discussing with patients. At the same time, the FDA has implemented an updated Risk Evaluation and Mitigation Strategy (REMS). If you insert or remove Nexplanon, this Nexplanon REMS requirement affects your ability to order, dispense, and place the implant. Here’s what you need to know to stay certified and avoid disruptions in care.

What are the recent Nexplanon updates?

Two updates were released together.

• Nexplanon FDA label updates:
  • Nexplanon is now approved for up to 5 years of pregnancy prevention (previously 3 years). Clinical trial data supporting the update found no pregnancies and no new safety concerns during years 4–5 of use.
  • Updated language regarding use in people with obesity: Clinical trial data demonstrated continued contraceptive effectiveness across a wide range of body mass index (BMI) values, including people with higher weight and obesity. The label no longer includes prior cautionary language about effectiveness in higher-BMI populations. More info can be found in the “Special Population” section of the label.
  • Updated language regarding pediatric use: Language noting the absence of clinical trials in individuals under age 18 has been removed, reflecting evidence of safety and effectiveness in women of reproductive potential, including adolescents.  
• FDA Nexplanon REMS requirements
  • All providers who insert or remove Nexplanon must now be REMS-certified, including those with prior experience.
  • This requirement applies to all providers performing the procedure, not just new trainees.

What do I have to do for the Nexplanon REMS requirement?

The steps required for certification depend on your prior training.

For providers currently placing Nexplanon AND who completed the 2019 label update training:

1. Create an account on the Nexplanon REMS website.
2. Review the Prescribing Information and Healthcare Provider Guide. 
3. Complete the Knowledge Assessment.
4. Submit the Enrollment Form.

After completing these steps, you should be REMS-certified and do not need additional training.

For providers who have not placed Nexplanon in the last 3 years and/or did not complete the 2019 label update training:

1. Create an account on the Nexplanon REMS website.
2. Review the Prescribing Information and Healthcare Provider Guide. 
3. Complete the Knowledge Assessment.
4. Submit the Enrollment Form.
5. Complete required online didactic and schedule in-person practical training.
6. Complete in-person practical training. 

Is there a deadline to complete the Nexplanon REMS requirement?

Yes. Providers must complete certification by August 23, 2026 to continue ordering and placing Nexplanon without interruption. 

Providers who miss the August 23, 2026 deadline will not be able to insert or remove Nexplanon until certification is completed.

Are there new insertion technique changes to Nexplanon?

There are no changes to the recommended insertion technique or location. The recommended insertion site remains 3–5 cm posterior (below) the sulcus between the biceps and triceps (updated in 2018 to reduce neurovascular injury and migration risk).

What if the Nexplanon REMS site doesn’t show my training record, even though I know I completed it?

According to Organon, if the REMS portal does not accurately reflect your prior training (for example, if you completed the 2019 label update training but the system indicates additional training is required), call 1-833-NXP-REMS (1-833-697-7367) for assistance. 

I’m a student (medical, nursing, PA, CNM) or resident. Do I need to be REMS certified to place Nexplanon as part of my training?

Yes. Students and residents must complete REMS certification to place Nexplanon as part of their training. For the most streamlined enrollment, enter both a state license number and NPI number. Students are eligible to apply for an NPI number.

If you don’t yet have a state license number, you can still enroll with your NPI number alone — if additional documentation is needed, you’ll be prompted during enrollment.

I am a pharmacist who dispenses Nexplanon. Do I have to complete the REMS?

Pharmacists must complete the REMS if they work at a pharmacy that participates in the Nexplanon restricted distribution program and serve as an authorized representative for that pharmacy. If you are unsure whether this applies to you, call 1-833-NXP-REMS (1-833-697-7367).